반응 #53888

ord-68464d84f237431c98f4ee8354cfc66f

반응 방정식

C1CCNCC1
piperidine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(Cl)cc1
4-chlorophenyl chloroformate
→
CN(C(=O)Oc1ccc(Cl)cc1)[C@H]1CC[C@H](CCCCCN2CCCCC2)CC1
trans-Methyl-[4-(5-piperidin-1-yl-pentyl)-cyclohexyl]-carbamic acid 4-chloro-phenyl ester

반응물

C1CCNCC1
piperidine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=C(Cl)Oc1ccc(Cl)cc1
4-chlorophenyl chloroformate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-chlorophenyl chloroformate were reacted, followed by treatment with piperidine to give trans-Methyl-[4-(5-piperidin-1-yl-pentyl)-cyclohexyl]-carbamic acid 4-chloro-phenyl ester, MS: 421 (MH+, 1Cl).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02