반응 #538441

반응 방정식

toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester

1-heptyne

→

1-(4-Hept-1-ynyl-3-methoxy-phenyl)ethanone

용매

heptane DCM

반응 조건

후처리

1. 1
   기타yield (110 mg, 90%)

실험 절차

This product was prepared from toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester and 1-heptyne following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: heptane/DCM 1:1; yield (110 mg, 90%); 1H NMR δ (CDCl3): 7.50-7.41 (m, 3H), 3.91 (s, 3H), 2.59 (s, 3H), 2.47 (t, J=7.14 Hz, 2H), 1.63 (p, J=7.22 Hz, 2H), 1.5-1.29 (m, 4H), 0.91 (t, J=7.13 Hz, 3H); LCMS m/z: 244.

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