반응 #53836

ord-9d9dadfec2a1402ab73e18658aa5eadf

반응 방정식

N[C@H]1CC[C@H](O)CC1
trans-4-amino-cyclohexanol
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)-benzenesulfonyl chloride
→
O=S(=O)(N[C@H]1CC[C@H](O)CC1)c1ccc(C(F)(F)F)cc1
trans-N-(4-Hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide

반응물

N[C@H]1CC[C@H](O)CC1
trans-4-amino-cyclohexanol
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)-benzenesulfonyl chloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to example 11.9, trans-4-amino-cyclohexanol and 4-(trifluoromethyl)-benzenesulfonyl chloride were converted to yield trans-N-(4-Hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide as white solid, 176.2° C., MS 322 (M-H).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02