반응 #53815

ord-7bf1ee4086c84864987babdfee03417c

반응 방정식

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCBr
1,3-dibromopropane
→
CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](OCCCBr)CC1
trans-[4-(3-Bromo-propoxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester

반응물

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCBr
1,3-dibromopropane

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 1.4 and 1.5, trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester was reacted with 1,3-dibromopropane to yield trans-[4-(3-Bromo-propoxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester which was reacted with N-allylmethylamine to yield trans-(4-[3-(Allyl-methyl-amino)-propoxy]-cyclohexyl)-methyl-carbamic acid tert-butyl ester as colorless oil, MS: 341 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02