반응 #538103

반응 방정식

Potassium carbonate

allyl bromide

4-chloro-3-methoxybenzoic acid

→

title compound

수율 98.0%

3-Methoxy-4-chloro-benzoic acid allyl ester

수율 98.0%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타The reaction mixture was partitioned between diethyl ether (200 ml) and water (150 ml)
2. 2
   추출the organic phase extracted
3. 3
   세척further washed with water (150 ml)
4. 4
   건조dried over sodium sulfate
5. 5
   농축concentrated in vacuo

실험 절차

Potassium carbonate (4.44 g, 32.156 mmol) and allyl bromide (2.78 ml, 32.156 mmol) were added to a stirred solution of 4-chloro-3-methoxybenzoic acid (3 g, 16.078 mmol) in N,N-dimethylformamide (30 ml) and allowed to stir at room temperature for 18 hours. The reaction mixture was partitioned between diethyl ether (200 ml) and water (150 ml), the organic phase extracted and further washed with water (150 ml), dried over sodium sulfate and concentrated in vacuo to afford the title compound as an orange oil in 98% yield, 3.57 g.

출처