반응 #537914

반응 방정식

N-(4-Amino-indan-2-ylmethyl)-propionamide

4-Isopropylbenzenesulfonyl chloride

→

product

수율 101.4%

N-[4-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide

수율 101.4%

용매

pyridine dichloromethane

반응 조건

후처리

1. 1
   기타Solution was evaporated
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   기타the organic phase separated
4. 4
   건조dried over MgSO4
5. 5
   농축The filtered solution was concentrated

실험 절차

N-(4-Amino-indan-2-ylmethyl)-propionamide (0.51 g, 2.34 mmol) was dissolved in pyridine-dichloromethane (1:2, 30 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.54 g, 2.47 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (0.95 g, 100%).

출처