반응 #537912

반응 방정식

N-(5-Amino-indan-2-ylmethyl)-propionamide

4-Isopropylbenzenesulfonyl chloride

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product

수율 99.0%

N-[5-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide

수율 99.0%

용매

pyridine dichloromethane

반응 조건

후처리

1. 1
   기타Solution was evaporated
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   기타the organic phase separated
4. 4
   건조dried over MgSO4
5. 5
   농축The filtered solution was concentrated

실험 절차

N-(5-Amino-indan-2-ylmethyl)-propionamide (0.93 g, 4.26 mmol) was dissolved in pyridine-dichloromethane (1:2, 60 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.98 g, 4.48 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (1.69 g, 99%).

출처