반응 #5374

반응 방정식

2-(4-hydroxyphenyl)-5-octylbenzooxazole

heptanoic acid

→

2-(4-heptanoyloxyphenyl)-5-octylbenzooxazole

수율 60.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.STIRRINGstirring at room temperature for 85 minutes
2. 2
   여과The resultant N,N'-dicyclohexylurea was filtered off
3. 3
   기타the filtrate was dried under reduced pressure
4. 4
   기타to precipitate a resultant
5. 5
   기타The resultant was purified by silica gel column chromatography (eluent: toluene)
6. 6
   기타recrystallized from acetone

실험 절차

In a 30 ml round-bottom flask, 0.50 g (1.55 m mole) of 2-(4-hydroxyphenyl)-5-octylbenzooxazole, 0.22 g (1.69 m mole) of heptanoic acid and 10 ml of dichloromethane were placed, followed by adding 0.32 g (1.55 m mole) of N,N-dicyclohexylcarbodiimide and 0.04 g of 4-pyrrodinopyridine in order at room temperature under stirring, and stirring at room temperature for 85 minutes. The resultant N,N'-dicyclohexylurea was filtered off and the filtrate was dried under reduced pressure to precipitate a resultant. The resultant was purified by silica gel column chromatography (eluent: toluene) and recrystallized from acetone to obtain 0.41 g of 2-(4-heptanoyloxyphenyl)-5-octylbenzooxazole (Yield: 60.9%). ##STR81##

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