반응 #537223

반응 방정식

sodium hydroxide

1-methyl-5-nitro-1H-indole

tin (II) chloride hydrate

→

1-methyl-1H-indol-5-ylamine

수율 28.9%

용매

ethyl acetate

반응 조건

후처리

1. 1
   추출the compound extracted
2. 2
   기타The crude compound obtained
3. 3
   기타was purified by column chromatography over silica gel

실험 절차

To 1-methyl-5-nitro-1H-indole (0.5 g, 2.84 mmol) in ethyl acetate (10 ml), tin (II) chloride hydrate (2.5 g, 11.4 mmol, 4 eq) was added and the reaction mixture stirred overnight at room temperature. The reaction mixture was basified with aqueous sodium hydroxide solution (pH 8) and the compound extracted using ethyl acetate. The crude compound obtained was purified by column chromatography over silica gel using ethyl acetate/hexane (1:1) as eluent to give 1-methyl-1H-indol-5-ylamine (120 mg, 27%).

출처