반응 #536705

반응 방정식

7-methoxy-1-tetralone

→

7-hydroxy-3,4-dihydronaphthalen-1(2H)-one

수율 110.1%

용매

hydrobromic acid

반응 조건

후처리

1. 1
   온도to cool to r.t.
2. 2
   기타partitioned between ethyl acetate and water
3. 3
   세척The organic layer was washed with brine
4. 4
   건조dried over magnesium sulfate
5. 5
   농축concentrated under reduced pressure

실험 절차

The 7-methoxy-1-tetralone (Aldrich, Cat. #163368) (0.75 g, 4.2 mmol) was dissolved in conc hydrobromic acid (3.0 ml) and was heated to 100° C. for 8 h. The reaction was allowed to cool to r.t. and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give crude 7-hydroxy-3,4-dihydronaphthalen-1(2H)-one (0.75 g, 100%) as a semisolid.Analytical LCMS (M+H)+: m/z=163.0.

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