반응 #53665

반응 방정식

N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide

iodotrimethylsilane

→

3,4-dichloro-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide

수율 80.1%

용매

chloroform

반응 조건

실험 절차

3,4-Dichloro-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 6 from 0.8 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-3,4-dichlorobenzenesulfonamide, 7.1 ml of chloroform and 0.25 ml of iodotrimethylsilane. 0.5 g of 3,4-dichloro-N-(3-methyl-1H-indazol-5-yl)benzenesulfonamide is thus obtained in the form of a white solid melting at 184° C. (analysis: C14H11Cl2N3O2S.0.04CH2Cl2 % calculated, C, 47.21; H, 3.11; Cl, 19.90; N, 11.80; O, 8.98; S, 9.00. % found C, 47.65; H, 2.56; Cl, 19.97; N, 11.89; S, 8.92).

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