반응 #536366

반응 방정식

methyl carbamate

2-oxo-4-(hydroxymethylphosphinyl)-butanoic acid

acetic acid

→

objective compound

수율 71.9%

(Z)-2-methoxycarbonylamino-4-(hydroxymethylphosphinyl)-2-butenoic acid

수율 71.9%

용매

toluene

반응 조건

후처리

1. 1
   workup.DISSOLUTIONAfter being dissolved
2. 2
   온도by heating
3. 3
   온도the solution was refluxed with vigorous stirring

실험 절차

67.56 g of methyl carbamate, 2.97 g of p-toluenesulfonic acid monohydrate and 108.06 g of 2-oxo-4-(hydroxymethylphosphinyl)-butanoic acid were added to 160 mL of acetic acid to be suspended. After being dissolved by heating, 800 mL of toluene was added thereto and then the solution was refluxed with vigorous stirring. According to the same procedure as Example 1, 102.28 g of the objective compound was obtained (71.9% yield, Z:E=99.8:0.2).

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