반응 #535893

반응 방정식

2′-C-methyladenosine

N-bromosuccinimide

→

desired product

수율 21.1%

8-Bromo-2′-C-methyladenosine

수율 21.1%

용매

DMF

반응 조건

후처리

1. 1
   기타evaporated in vacuo
2. 2
   기타The crude product was purified on a silica gel column (3×9 cm)
3. 3
   workup.ADDITIONFractions containing the product
4. 4
   기타evaporated in vacuo

실험 절차

To a solution of 2′-C-methyladenosine [for preparation, see J. Med. Chem. 41: 1708 (1998)] (138 mg, 0.5 mmol) in DMF (4 mL) was added N-bromosuccinimide (231 mg, 1.35 mmol). The solution was stirred protected from light at rt for 2 d and then evaporated in vacuo. The crude product was purified on a silica gel column (3×9 cm) using dichloromethane/methanol (25/1, 20/1 and 15/1) as eluent. Fractions containing the product were pooled and evaporated in vacuo to give the desired product (38 mg) as a white solid.

출처