반응 #535331

반응 방정식

Compound 2

4-cyclopropylnaphthalen-1-amine

Sodium bicarbonate

thiophosgene

→

1-cyclopropyl-4-isothiocyanatonaphthalene

수율 149.7%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타Then, the organic layer was separated
2. 2
   건조dried over sodium sulfate
3. 3
   농축concentrated

실험 절차

Compound 2 (440 mg, 2.6 mmol) was dissolved in 14 mL of dichloromethane. Sodium bicarbonate (7 mL, sat. solution) and thiophosgene (0.2 mL, 2.6 mmol) were added and the mixture stirred at room temperature for 1 h. Then, the organic layer was separated, dried over sodium sulfate and concentrated to afford 877 mg, 99% yield of 1-cyclopropyl-4-isothiocyanatonaphthalene (3) which was used in the next step without further purification

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