반응 #53514

반응 방정식

glycidyl tosylate

2-amino-3-nitrophenol

K2CO3

→

title compound

2-amino-3-nitro-1-(2,3-epoxypropoxy)benzene

용매

acetone

반응 조건

후처리

1. 1
   온도the mixture is heated
2. 2
   온도at reflux for 18 hours
3. 3
   여과The mixture is filtered
4. 4
   기타the solvent is evaporated under reduced pressure
5. 5
   기타The crude reaction product
6. 6
   기타is purified by flash chromatography, elution

실험 절차

21.7 g (0.095 mol) of glycidyl tosylate, 10 g (0.0475 mol) of 2-amino-3-nitrophenol and 6.5 g of crushed K2CO3 are mixed in acetone and the mixture is heated at reflux for 18 hours. The mixture is filtered and the solvent is evaporated under reduced pressure. The crude reaction product is purified by flash chromatography, elution being carried out with a 9/1 hexane/ethyl acetate mixture. The title compound is obtained. M.p.: 7°-78° C.

출처