반응 #53513

ord-007fab9badaf4c7ca8c9d853d77769da

반응 방정식

Cl
hydrochloric acid
CCOC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)nc1
product
CCOC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)nc1
4-tert-butoxycarbonylamino-1-(5-ethoxycarbonyl-pyrid-2-yl) piperidine
→
CCOC(=O)c1ccc(N2CCC(N)CC2)nc1
title product
CCOC(=O)c1ccc(N2CCC(N)CC2)nc1
4-amino-1-(5-ethoxycarbonylpyrid-2-yl)piperidine

반응물

—
solution
Cl
hydrochloric acid
CCOC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)nc1
product
CCOC(=O)c1ccc(N2CCC(NC(=O)OC(C)(C)C)CC2)nc1
4-tert-butoxycarbonylamino-1-(5-ethoxycarbonyl-pyrid-2-yl) piperidine

시약

없음

용매

CCOC(C)=O
ethyl acetate
CCOC(C)=O
ethyl acetate

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.WAITthe mixture is left
  2. 2
    여과The product is filtered off
  3. 3
    세척washed with acetone

실험 절차

The product of stage b) is dissolved in ethyl acetate, a 3N solution of hydrochloric acid in ethyl acetate is added and the mixture is left stirring at ambient temperature for 10 hours. The product is filtered off and washed with acetone. The title product is obtained. M.p.: 148-150° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858629B1uspto-grants-2005_02