반응 #53430

반응 방정식

4-methylphenyl-acetic acid

tert-butanol

dicyclohexylcarbodiimide

→

tert-Butyl 4-methylphenyl-acetate

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   여과the precipitated urea is filtered off with suction
2. 2
   세척the organic phase is washed twice each with 500 ml of 2 M hydrochloric acid and water
3. 3
   농축The organic phase is concentrated
4. 4
   workup.DISTILLATIONdistilled

실험 절차

450 g (3 mol) of 4-methylphenyl-acetic acid (Aldrich), 1.13 l (12 mol) of tert-butanol and 90 g (0.74 mol) of 4-(N,N-dimethylamino)pyridine are dissolved in 2 l of dichloromethane. After addition of 680 g (3.3 mol of dicyclohexylcarbodiimide, dissolved in 400 ml of dichloromethane, the mixture is stirred at 25° C. for 20 h, the precipitated urea is filtered off with suction and flashed with 200 ml of dichloromethane, and the organic phase is washed twice each with 500 ml of 2 M hydrochloric acid and water. The organic phase is concentrated and distilled.

출처