반응 #5337

반응 방정식

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

용매

dioxane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated to dryness
2. 2
   기타The residue was crystallized from ethyl acetate (50 ml)
3. 3
   기타Resulting crystalline precipitates
4. 4
   여과were collected by filtration

실험 절차

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

출처