반응 #5335

반응 방정식

water

methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

4'-bromomethylbiphenyl-2-carboxamide

K2CO3

→

syrup

수율 90.0%

Methyl 2-[N-tert-butoxycarbonyl-N-(2'-carbamoylbiphenyl-4-yl)methylamino1-3-nitrobenzoate

수율 90.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도was heated for 6 hours
2. 2
   온도under reflux
3. 3
   추출the mixture was extracted with ethyl acetate
4. 4
   세척The extract was washed with water
5. 5
   건조dried over MgSO4
6. 6
   기타The solvent was removed in vacuo
7. 7
   기타the residue was purified by column chromatography on silica gel

실험 절차

A mixture of methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate (1.8 g), 4'-bromomethylbiphenyl-2-carboxamide (1.8 g) and K2CO3 (0.86 g) in acetonitrile (25 ml) was heated for 6 hours under reflux. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over MgSO4. The solvent was removed in vacuo, and the residue was purified by column chromatography on silica gel to afford a yellow syrup (2.3 g, 90%).

출처