반응 #53344

반응 방정식

starting material I

(±)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

3-chloro-2-butanone

→

title compound

수율 76.0%

(±)-7-(4,5-Dimethyl-thiazol-2-yl)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

수율 76.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도After cooling the precipitated crystals
2. 2
   여과were filtered off
3. 3
   기타dried
4. 4
   기타purified by recrystallization from dimethylformamide and water

실험 절차

A mixture of 0.60 g (1.56 mmol) of the starting material I, 1.02 g (9.57 mmol) of 3-chloro-2-butanone and 8 ml of dimethylformamide was stirred at 90° C. for 3 h. After cooling the precipitated crystals were filtered off, dried and purified by recrystallization from dimethylformamide and water to yield 0.49 g (76%) of the title compound; Mp.: >260° C. (dec.).

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