반응 #53342

반응 방정식

starting material I

(±)-8-Methyl-5-(4-nitrophenyl)-7-thiocarbamoyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

chloroacetone

dimethylformamide

→

title compound

수율 82.5%

(±)-8-Methyl-7-(4-methyl-thiazol-2-yl)-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

수율 82.5%

용매

water

반응 조건

후처리

1. 1
   여과the precipitated crystals were filtered off
2. 2
   기타dried
3. 3
   기타purified
4. 4
   온도by refluxing in ethanol

실험 절차

A mixture of 0.76 g (1.98 mmol) of the starting material I, 1.10 g (11.88 mmol) of chloroacetone and 15 ml of dimethylformamide was stirred at 80-90° C. for 40 min. Then the reaction mixture was diluted with water, the precipitated crystals were filtered off, dried and purified by refluxing in ethanol to yield 0.69 g (82%) of the title compound; Mp.: 188-189° C.

출처