반응 #533371

반응 방정식

α,α′-dibromo-m-xylene

2-cyano-6-hydroxybenzothiazole

potassium carbonate

→

product

수율 91.7%

2-cyano-6-(3-bromomethylbenzyloxy)benzothiazole

수율 91.7%

용매

acetone

반응 조건

후처리

1. 1
   기타the solvent was removed under reduced pressure
2. 2
   세척washed with water
3. 3
   추출The aqueous phase was extracted with more dichloromethane (2×)
4. 4
   건조dried over sodium sulfate
5. 5
   기타purified by flash chromatography

실험 절차

To a solution of 2-cyano-6-hydroxybenzothiazole (1.04 g) in 30 mL of acetone was added potassium carbonate (1.63 g), followed by α,α′-dibromo-m-xylene (4.7 g). The resultant solution was stirred at RT for 1 hour and the solvent was removed under reduced pressure. The residue was resuspended in dichloromethane and washed with water. The aqueous phase was extracted with more dichloromethane (2×) and the organic extracts were combined, dried over sodium sulfate, and purified by flash chromatography using dichloromethane. 1.945 g of product was obtained.

출처