반응 #5333

반응 방정식

methyl 3-iodobenzoate

toluene

→

title compound

수율 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

수율 29.0%

용매

4-iodotoluene

반응 조건

후처리

1. 1
   여과Insoluble materials were filtered off
2. 2
   농축the filtrate was concentrated to dryness
3. 3
   기타The residue was purified by column chromatography on silica gel

실험 절차

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

출처