반응 #53321

반응 방정식

Iodomethane

4-cyanophenyl-thiourea

→

methyl N′-(4-cyanophenyl)-carbamimidothioate

수율 84.0%

용매

acetone

반응 조건

후처리

1. 1
   여과The precipitate was filtered off
2. 2
   기타dried
3. 3
   workup.DISSOLUTIONdissolved in DCM
4. 4
   세척The organic solution was washed with NH3 (aq.) (excess)
5. 5
   건조dried with potassium carbonate
6. 6
   여과filtered
7. 7
   기타the solvent was evaporated

실험 절차

Iodomethane (1.76 ml) was added to 4-cyanophenyl-thiourea (5.0 g) in acetone (100 ml). The reaction mixture was stirred overnight at RT. The precipitate was filtered off, dried and dissolved in DCM. The organic solution was washed with NH3 (aq.) (excess), dried with potassium carbonate, filtered, and the solvent was evaporated, yielding 4.53 g (84%, white solid) of methyl N′-(4-cyanophenyl)-carbamimidothioate (intermediate 6).

출처