반응 #53309

반응 방정식

Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyrate

bromine

→

title compound

Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-3-bromobutyrate

용매

ether

ether

반응 조건

후처리

1. 1
   기타reaction mixture
2. 2
   농축was concentrated
3. 3
   기타purified by flash chromatography on silica gel column (EtOAc:Hex, 1:4)

실험 절차

To a ice cooled solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyrate (Step C, 3 g, 9 mmol) in dry ether (70 ml) was added dropwise bromine (0.7971 g, 9.9 mmol) diluted in ether (30 ml). After 4 hours of stirring, reaction mixture was concentrated and purified by flash chromatography on silica gel column (EtOAc:Hex, 1:4) to provide the title compound.

출처