반응 #53278

반응 방정식

PBr3

pyridine

4-Hydroxybenzyl alcohol

→

title compound

4-Hydroxybenzyl bromide

용매

THF

THF

THF

THF

반응 조건

후처리

1. 1
   여과filtered through celite pad
2. 2
   기타The filtrate was evaporated
3. 3
   workup.DISSOLUTIONthe resulting semisolid was redissolved in dry toluene (16 ml)
4. 4
   여과filtered through celite pad

실험 절차

To a stirred solution of PBr3 (1.38 g, 5.0 mmol) in dry THF (2 ml) at −5° C. was added a solution of dry pyridine (0.201 ml) in dry THF (0.4 ml). A solution of 4-Hydroxybenzyl alcohol (1.89 g, 15.2 mmol) in dry THF (23 ml) was added drop wise to the reaction mixture. The reaction mixture was allowed to stand at room temperature for 18 hours, then diluted with THF and filtered through celite pad. The filtrate was evaporated, the resulting semisolid was redissolved in dry toluene (16 ml). The solution was maintained at −20° C. for 2 hours, and then filtered through celite pad to provide the title compound as a light yellow solution which was used without further purification.

출처