반응 #53276

반응 방정식

tert-Butyl 4-(4-(2-fluorobenzyloxy)phenyl)-4-oxobutyrate

trifluoroacetic acid

→

title compound

4-(4-(2-Fluorobenzyloxy)phenyl)-4-oxobutyric acid

용매

dichloromethane

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타The purification

실험 절차

A solution of tert-Butyl 4-(4-(2-fluorobenzyloxy)phenyl)-4-oxobutyrate (Step B, 1.27 g, 4.2 mmol) in dichloromethane (25 ml) was treated with trifluoroacetic acid (5 ml). The reaction mixture was stirred at ambient temperature for 3 hours and concentrated in vacuo. The purification was done by flash chromatography on silica gel column (chloroform: methanol, 95:5 spiked with acetic acid) to afford the title compound as a white powder.

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