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8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Intermediate A

8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

5-methylpyridine-3-boronic acid

→

title compound

1-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-methyl-8-(5-methyl-pyridin-3-yl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

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후처리

1. 1
   기타The title compound was synthesized in a similar manner

실험 절차

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 40 mg, 0.105 mmol) and 5-methylpyridine-3-boronic acid (Combi-Blocks, San Diego, USA, 17 mg, 0.123 mmol) to give the title compound as an off-white solid. (HPLC: tR 2.07 min (Method A); M+H=385 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.98 (s, 1H), 8.54-8.48 (m, 1H), 8.45-8.39 (m, 1H), 8.19-8.08 (m, 2H), 7.99-7.92 (m, 1H), 7.71-7.66 (m, 1H), 7.58-7.53 (m, 1H), 3.92 (s, 3H), 3.59 (s, 3H), 2.37 (s, 3H), 1.95 (s, 3H))

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