반응 #53271

반응 방정식

tetraethylene glycol

NaOH

benzyl chloride

→

title compound

수율 71.0%

Tetraethylene glycol monobenzylether

수율 71.0%

용매

NaCl

반응 조건

후처리

1. 1
   workup.STIRRINGstirred overnight
2. 2
   온도The reaction mixture was cooled to room temperature
3. 3
   세척washed CH2Cl2 (2×200 mL)
4. 4
   세척washed sat. NaCl, dried MgSO4
5. 5
   기타chromatographed (silica, ethyl acetate)

실험 절차

To the oil of non-polydispersed tetraethylene glycol (19.4 g, 0.10 mol) was added a solution of NaOH (4.0 in 4.0 mL) and the reaction was stirred for 15 min. Then benzyl chloride (3.54 mL, 30.8 mmol) was added and the reaction mixture was heated to 100° C. and stirred overnight. The reaction mixture was cooled to room temperature, diluted with sat. NaCl (250 mL), and washed CH2Cl2 (2×200 mL). The organic layers were combined, washed sat. NaCl, dried MgSO4, and chromatographed (silica, ethyl acetate) to afford the non-polydispersed title compound as a yellow oil (6.21 g, 71% yield).

출처