반응 #53260

반응 방정식

3-hydroxymyristic acid

triethylamine

benzyl bromide

→

benzyl 3-hydroxymyristate

용매

DMF

반응 조건

후처리

1. 1
   기타After the solvent was removed in vacuo, to the residue
2. 2
   workup.ADDITIONwere added ethyl acetate and water
3. 3
   세척The separated ethyl acetate layer was washed twice with water
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   기타After the ethyl acetate was removed in vacuo, purification

실험 절차

To a solution of 3-hydroxymyristic acid (5.00 g) and triethylamine (2.85 g) in DMF (50 ml) was added benzyl bromide (2.43 ml) and the mixture was stirred at room temperature overnight. After the solvent was removed in vacuo, to the residue were added ethyl acetate and water. The separated ethyl acetate layer was washed twice with water and then dried over anhydrous sodium sulfate. After the ethyl acetate was removed in vacuo, purification was carried out by a silica gel column chromatography (silica gel 30 g, chloroform:methanol=100:0-10) to afford 3.69 g of benzyl 3-hydroxymyristate.

출처