반응 #532330

반응 방정식

2-amino-4,5-dimethoxy-benzonitrile

potassium carbonate

2-iodo-propane

→

2-isopropylamino-4,5-dimethoxy-benzonitrile

반응 조건

후처리

1. 1
   농축Extractive work-up with ethyl acetate/water and concentration i.V
2. 2
   기타affords a dark oil, which
3. 3
   기타is purified by flash chromatography (ethyl acetate/hexane)

실험 절차

A suspension of 4.52 g (25.4 mmol) 2-amino-4,5-dimethoxy-benzonitrile, 4.38 g (31.7 mmol) potassium carbonate and 100 mg copper powder in 15 ml 2-iodo-propane is stirred at 90° C. for 5 days. Extractive work-up with ethyl acetate/water and concentration i.V. affords a dark oil, which is purified by flash chromatography (ethyl acetate/hexane). yield: 4.15 g (74%) yellow oil.

출처