반응 #53211

반응 방정식

dimethylamine

4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene

→

4-(3-dimethylaminoprop-1-ynyl)-nitrobenzene

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척Then the reaction solution is washed with water
2. 2
   기타The residue is chromatographed on silica gel (dichloromethane/methanol=10:1)
3. 3
   기타The product is obtained as an oil

실험 절차

190 ml (4.2 mmol) of dimethylamine dissolved in 2.5 ml of dichloromethane are added dropwise at 0° C. to a solution of 0.7 g (2.1 mmol) of 4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene in 10 ml of dichloromethane. The cooling is stopped and the mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol=10:1). The product is obtained as an oil.

출처