반응 #53209
ord-7d8c42409bc3412a8e79172bc76b0462
반응 조건
온도
100°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척It is washed with water and ammonia water
- 2여과filtered through Celite
- 3기타The product is obtained by chromatography on silica gel (dichloromethane/methanol=10:1)
실험 절차
8.55 g (0.15 mol) of propargyl alcohol and 152 ml (110 g, 1.09 mol) of triethylamine are added to a solution of 20.2 g (0.1 mol) of 4-bromonitrobenzene in 285 ml of acetonitrile. The reaction solution is heated to 100° C. 11.9 g (10 mmol) of Pd(Pph3)4 and 3.94 g (20 mmol) of copper (I) iodide are added. After 10 minutes the solvent is eliminated in vacuo and the residue taken up in ethyl acetate. It is washed with water and ammonia water, filtered through Celite and the solvent is eliminated in vacuo. The product is obtained by chromatography on silica gel (dichloromethane/methanol=10:1).