반응 #531834

반응 방정식

N-butyl-N-methylamine

diisopropylcarbodiimide

diisopropylcarbodiimide

→

guanidine

수율 100.0%

1-Butyl-2,3-diisopropyl-1-methylguanidine

수율 100.0%

반응 조건

후처리

1. 1
   온도is heated
2. 2
   온도at reflux for 3 hours
3. 3
   농축is concentrated at 60° C. under 5 mbar for 2 hours
4. 4
   기타to give 40 g of a colorless and virtually odorless liquid of low viscosity, which

실험 절차

A mixture of 32.68 g of N-butyl-N-methylamine (0.375 mol) and 23.66 g of diisopropylcarbodiimide (0.1875 mol) is heated at reflux for 3 hours. GC analysis then shows a conversion of more than 99.5% of the diisopropylcarbodiimide. The final mixture, which is colorless, is concentrated at 60° C. under 5 mbar for 2 hours, to give 40 g of a colorless and virtually odorless liquid of low viscosity, which corresponds to the expected guanidine (100% yield).

출처