반응 #531804

반응 방정식

Acetic acid

4-pentynoic acid

N-hydroxy succinimide

DCC

→

10a

수율 100.5%

Pent-4-ynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

수율 100.5%

용매

THF

반응 조건

후처리

1. 1
   workup.WAITthen left
2. 2
   workup.STIRRINGto stir at room temperature overnight
3. 3
   workup.WAIT(A white precipitate was observed after 15 min
4. 4
   기타The resulting DCU was removed by filtration
5. 5
   기타The filtrate was then evaporated

실험 절차

4-pentynoic acid (5.0 g, 51 mmol) and N-hydroxy succinimide (5.87 g, 51 mmol) were added to a solution of DCC (12.6 g, 61.2 mmol) in THF (125 ml) at −10° C. The mixture was then stirred for 1 h at −10° C. then left to stir at room temperature overnight. (A white precipitate was observed after 15 min). Acetic acid (0.63 ml) was then added. The resulting DCU was removed by filtration. The filtrate was then evaporated to give 10a (10 g, 100% crude yield).

출처