반응 #531790

반응 방정식

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

수율 95.7%

3-(tritylthio) propanoic acid

수율 95.7%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타were carried out at room temperature
2. 2
   여과was filtered
3. 3
   세척was rinsed with 40 ml of diethyl ether
4. 4
   기타The precipitate was then dried under reduced pressure

실험 절차

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

출처