반응 #53169

ord-b27bcf3f1e8043e281f92c85bebdc2d9

반응 방정식

$CS(=O)(=O)N(CC(=O)O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

2-dimethylamino-ethylamine

HOBt

CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

TBTU

N-ethyl-N,N-diisopropylamine

→

$CN(C)CCNC(=O)CN(c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1)S(C)(=O)=O$

(Z)-3-{1-[4-(N-(2-dimethylamino-ethylaminocarbonylmethyl)-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

반응물

$CS(=O)(=O)N(CC(=O)O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1$

(Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone

2-dimethylamino-ethylamine

HOBt

TBTU

N-ethyl-N,N-diisopropylamine

시약

없음

용매

DMF

반응 조건

상세 조건

See reaction.notes.procedure_details.

실험 절차

Prepared analogously to Example 18 from (Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone, 2-dimethylamino-ethylamine, HOBt, TBTU and N-ethyl-N,N-diisopropylamine in DMF.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06855710B2uspto-grants-2005_02