반응 #531657

반응 방정식

hydrochloric ether

3,4-dihydroxyphenyl chloromethylketone

4-(2-oxobenzimidazolin-1-yl)piperidine

sodium carbonate

→

1-(3,4-dihydroxy phenacyl)-4-(2-oxobenzimidazolin-1-yl)piperidine hydrochloride

수율 107.7%

용매

hydrochloride

methanol

methylethyl ketone

반응 조건

후처리

1. 1
   기타After the completion of the reaction
2. 2
   여과the precipitate was filtered off
3. 3
   세척washed with water
4. 4
   기타After drying
5. 5
   기타there were obtained 14 g of raw base which

실험 절차

A suspension of 6.87 g of 3,4-dihydroxyphenyl chloromethylketone (trade product) and 8 g of 4-(2-oxobenzimidazolin-1-yl)piperidine (trade product), M.P. 183°-185° C., in 640 ml of methylethyl ketone, in the presence of 1.95 g of dried sodium carbonate and 0.1 g of sodium iodide, was refluxed for 12 hours. After the completion of the reaction, the precipitate was filtered off and washed with water. After drying, there were obtained 14 g of raw base which is transformed in hydrochloride in methanol by addition of hydrochloric ether. There were obtained 8 g of 1-(3,4-dihydroxy phenacyl)-4-(2-oxobenzimidazolin-1-yl)piperidine hydrochloride, white crystals melting at 310°-313° C.

출처