반응 #53162

반응 방정식

N-methylsulphonyl-4-nitroaniline

potassium tert.butoxide

bromoacetonitrile

→

N-cyanomethyl-N-methylsulphonyl-4-nitroaniline

용매

DMSO

반응 조건

후처리

1. 1
   workup.ADDITIONare added dropwise
2. 2
   workup.ADDITIONis poured onto ice water
3. 3
   추출extracted with ethyl acetate
4. 4
   세척The organic phase is washed with water
5. 5
   기타The residue thus obtained
6. 6
   기타is recrystallised from ethanol

실험 절차

3.24 g (15 mmol) of N-methylsulphonyl-4-nitroaniline are dissolved in 25 ml of DMSO and a total of 2.0 g (18 mmol) of potassium tert.butoxide are added batchwise. After 1 hour stirring at ambient temperature 2.7 g (23 mmol) of bromoacetonitrile are added dropwise. After 3 hours stirring at ambient temperature the mixture is poured onto ice water and extracted with ethyl acetate. The organic phase is washed with water and the solvent is eliminated in vacuo. The residue thus obtained is recrystallised from ethanol.

출처