반응 #5313

반응 방정식

4-Methoxybenzeneethanol

1,6-dibromohexane

NaOH

→

oil

1-[2-[(6-Bromohexyl)oxy]ethyl]-4-methoxybenzene

용매

H2O

반응 조건

후처리

1. 1
   추출extracted with ER (3×150 ml)
2. 2
   세척the combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml)
3. 3
   기타dried
4. 4
   기타evaporated

실험 절차

4-Methoxybenzeneethanol (5.0 g) and 1,6-dibromohexane (23.7 g) were stirred rapidly at RT with tetra-n-butyl ammonium bisulphate (0.94 g) and 12.5 M aqueous NaOH (30 ml) for 16 h. The mixture was diluted with H2O (125 ml), extracted with ER (3×150 ml) and the combined organic extracts were washed consecutively with H2O (125 ml), BR (125 ml), dried and evaporated to give an oil (24.6 g). The oil was purified by [FCS] eluting with ER-CX (0:100→4:96) to give the title compound as a colourless oil (8.30 g). T.l.c. (CX-ER (40:1)) Rf 0.33.

출처