반응 #531055

반응 방정식

sodium methoxide

4-fluorobenzylcyanide

acrylonitrile

sodium methoxide

sodium methoxide

→

2-(4-fluorophenyl)glutaronitrile

4-fluorobenzylcyanide

용매

toluene

methanol

반응 조건

후처리

1. 1
   기타an exothermic reaction
2. 2
   세척washed with water
3. 3
   기타The toluene is removed by evaporation
4. 4
   기타the residue is separated into its components by fractional distillation

실험 절차

Twenty-five g of 4-fluorobenzylcyanide is mixed with approximately 3.5 ml of freshly distilled acrylonitrile in a suitable reaction vessel. To this stirred mixture is added dropwise a solution of 80 mg of sodium methoxide in 1 ml of methanol. When about half of the sodium methoxide is added, there is an exothermic reaction. After all the sodium methoxide is added, the mixture is kept on a steam-bath for 2 hours and is then dissolved in toluene and washed with water. The toluene is removed by evaporation and the residue is separated into its components by fractional distillation to give 18 g of 4-fluorobenzylcyanide, and 2 g of 2-(4-fluorophenyl)glutaronitrile, bp 118°-122° C. at 0.03 mm.

출처