반응 #5310

반응 방정식

Dihydropyran

4-chlorobutanol

→

title compound

수율 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

수율 89.9%

반응 조건

후처리

1. 1
   세척washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   온도The dried liquid was heated under reduced pressure

실험 절차

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

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