반응 #530711

반응 방정식

p-nitrobenzyl 7-amino-3-methylenecepham-4-carboxylate hydrochloride

methanol

→

p-nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate

반응 조건

후처리

1. 1
   기타ozone is bubbled through the solution at a temperature of about -78° C
2. 2
   기타Excess ozone is purged from the mixture with nitrogen
3. 3
   기타by bubbling sulfur dioxide through the mixture
4. 4
   기타The reaction mixture is evaporated to dryness

실험 절차

In a further example, p-nitrobenzyl 7-amino-3-methylenecepham-4-carboxylate hydrochloride is dissolved in methanol and ozone is bubbled through the solution at a temperature of about -78° C. Excess ozone is purged from the mixture with nitrogen and the ozonide is decomposed by bubbling sulfur dioxide through the mixture. The reaction mixture is evaporated to dryness and the residue, p-nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate is obtained as the hydrochloride salt.

출처