반응 #53005

반응 방정식

hydrochloric acid

1-acetyl-2-indolinone

benzoic acid

TBTU

HOBt

N-ethyl-N,N-diisopropyl-amine

→

1-acetyl-3-(1-hydroxy-1-phenyl-methylidene)-2-indolinone

용매

DMF

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타dried at 60° C.

실험 절차

880 mg (5 mmol) of 1-acetyl-2-indolinone and 610 mg (5 mmol) of benzoic acid are dissolved in 15 ml of DMF and after the addition of 1.8 g (5.5 mmol) of TBTU, 840 mg (5.5 mmol) of HOBt and 3.2 g (25 mmol) of N-ethyl-N,N-diisopropyl-amine are stirred for 16 hours at ambient temperature. The solution is stirred into dilute hydrochloric acid, the precipitate is suction filtered and dried at 60° C.

출처