반응 #529886

반응 방정식

1,2-Epoxy-3-octadecyloxypropane

piperazine

potassium carbonate

chloroform

→

1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine

용매

dimethyl formamide

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타to leave a residue
3. 3
   여과The undissolved material is filtered in vacuo
4. 4
   농축the filtrate is concentrated in vacuo
5. 5
   기타purified by chromatography
6. 6
   기타dried in vacuo

실험 절차

1,2-Epoxy-3-octadecyloxypropane (5.0 g, 15.3 mmol) is added to a mixture of piperazine (1.94 g, 22.5 mmol) and anhydrous potassium carbonate (100 mg) in dimethyl formamide (60 mL) over a 30 minute period under a nitrogen atmosphere. The resultant mixture is stirred at 80°-90° C. (oil bath temperature) for 48 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to leave a residue. The residue is stirred with chloroform (125 mL). The undissolved material is filtered in vacuo, and the filtrate is concentrated in vacuo, purified by chromatography and dried in vacuo to afford 1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine.

출처