반응 #52986

반응 방정식

3,5-dimethoxybenzyl alcohol

tert-butyl-diphenylsilyl chloride

imidazole

→

3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether

수율 87.9%

용매

DMF

반응 조건

후처리

1. 1
   기타DMF was evaporated
2. 2
   기타the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% )

실험 절차

A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% ) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).

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