반응 #52983

반응 방정식

3,5-dimethoxybenzyl alcohol

t-butyl-diphenylsilyl chloride

imidazole

→

3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene

수율 87.9%

반응 조건

후처리

1. 1
   기타DMF was evaporated
2. 2
   기타the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%)

실험 절차

A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), t-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DML (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%) to yield 8.5 g of 3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene. ESMS: m/z 407 (MH+).

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