반응 #529760

반응 방정식

Methyl chloroformate

compound 3

4'-Hydroxy-4-biphenylcarboxylic acid

sodium hydroxide

hydrochloric acid

→

4'-Methoxycarbonyloxy-4-biphenylcarboxylic acid

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONDuring the addition a white precipitate
2. 2
   기타was formed
3. 3
   여과the resultant voluminous white solid was filtered off
4. 4
   세척washed with water until acid-free and
5. 5
   건조dried (phosphorus pentoxide) in vacuo

실험 절차

Methyl chloroformate (12.90 g, 0.137 mol) was added dropwise, over 10 minutes, to a stirred, cooled (5° C.) solution of compound 3 (10.00 g, 0.047 mol) in sodium hydroxide (5.44 g, 0.136 mol) and water (150 ml). During the addition a white precipitate was formed and this stirred mixture was allowed to warm to room temperature overnight. The resultant mixture was carefully acidified (pH 5) with dilute hydrochloric acid and the resultant voluminous white solid was filtered off, washed with water until acid-free and dried (phosphorus pentoxide) in vacuo.

출처