반응 #529378

ord-c0476045c1a54613abb05dc7d8927e31

반응 방정식

COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)c2ccc(Cl)cc2)C1c1ccccc1[N+](=O)[O-]
2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid α-methyl-4-chlorobenzyl ester
→
COC(=O)CC(=O)/C=C/c1ccccc1[N+](=O)[O-]
2'-nitrobenzylideneacetoacetic acid methyl ester
C/C(N)=C/C(=O)OC(C)c1ccc(Cl)cc1
β-aminocrotonic acid α-methyl-4-chlorobenzyl ester

반응물

COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)c2ccc(Cl)cc2)C1c1ccccc1[N+](=O)[O-]
2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid α-methyl-4-chlorobenzyl ester

시약

없음

용매

CCO
ethanol
CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid α-methyl-4-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid α-methyl-4-chlorobenzyl ester of melting point 206° C (from ethanol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04044141uspto-grants-1977_08