반응 #529351

ord-644c7155767244a9b770b116b9974853

반응 방정식

CC1=C(C(=O)OCc2ccc(Cl)c(Cl)c2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC(C)C)=C(C)N1
2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3, 4-dichlorobenzyl ester
CCO
ethanol
→
C/C(N)=C/C(=O)OCc1ccc(Cl)c(Cl)c1
β-aminocrotonic acid 3,4-dichlorobenzyl ester
수율 75.0%

반응물

CC1=C(C(=O)OCc2ccc(Cl)c(Cl)c2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC(C)C)=C(C)N1
2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3, 4-dichlorobenzyl ester
CCO
ethanol

시약

없음

용매

CC(C)O
isopropanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Analogously to Example 1 eating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 3,4-dichlorobenzyl ester in 120 ml of isopropanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3, 4-dichlorobenzyl ester of melting point 155° C (from ethanol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04044141uspto-grants-1977_08